|
KMID : 0881720230380050305
|
|
Journal of Food Hygiene and Safety
2023 Volume.38 No. 5 p.305 ~ p.310
|
|
|
Human Androgen Receptor-Mediated Endocrine Disrupting Potential of Parabens and Triclosan
|
|
Kim Ji-Won
Lee Hee-Seok
|
|
|
Abstract
|
|
|
|
This study aimed to determine the human androgen receptor (AR)?mediated endocrine disrupting potential of parabens and triclosan in food and household products using a cell-based assay in the OECD TG No.458, the 22Rv1/MMTV_GR-KO transcriptional activation assay. Four parabens (methyl-, ethyl-, propyl-, and butyl-) are determined as AR antagonists in OECD TG No.458. However, their AR antagonistic effects were not exhibited in the presence of the S9 hepatic fraction. Triclosan is also classified as an AR antagonist, and the AR antagonistic effect induced by triclosan significantly decreased in the presence of the phase I + II S9 fraction. Regarding the mechanism of AR antagonism induced by parabens and triclosan, the AR-mediated endocrine disrupting effects were exhibited through suppressing the translocation of ligand-bound AR to the nucleus via blocking of AR dimerization in the cytosol. These results indicate that the four parabens and triclosan have AR-mediated endocrine disrupting potential through an AR antagonistic effect via inhibiting AR dimerization; however, their endocrine disrupting effects deceased in the presence of hepatic metabolic enzymes.
|
|
|
KEYWORD
|
|
|
Parabens, Triclosan, Androgen receptor, Antagonist, Hepatic metabolites
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|